![]() I will conclude by commenting on the implications of these models to understanding the biophysical mechanisms underlying the interaction of ciliated tissues with microbial partners. Kaprielian Fellow in Engineering and professor in the AME department, was featured in KQED’s Deep Look into sea star motion. Here, I will present a series of physics-based models that take into account minimal cilia features in order to examine: (1) the emergence of self-sustained oscillations in individual cilia, (2) the coordinated beating of neighboring cilia, and (3) the role of cilia-driven flows in particle transport, mixing, capture and filtering. Yet, the relationship between the structure and organization of ciliated tissues and their biological function remains elusive. The derived equations are consistent with Lighthill’s reactive force theory for the swimming of slender bodies and, when neglecting vorticity, reduce to the model developed in Kanso et al. On the tissue level, cilia beat in a coordinated way and serve diverse biological functions, from mucociliary clearance in the airways to cerebrospinal fluid transport in the brain ventricles. Kanso, Eva: Aerospace & Mechanical Engineering: : Khoshnevis. Individual cilia are driven into oscillatory motion by dynein molecular motors acting on an intricate structure of microtubule doublets referred to as the central axoneme. : Heather Culbertson Computer Science : SK Gupta. Motile cilia are micron-scale hair-like protrusions from epithelial cells that beat collectively to transport fluid. Science Foundation Integrated NSF Support Promoting Interdisciplinary Research and Education Grant (NSF-MCB1608744) (to M.M.-N., E.G.R., and E.
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